Preheat oven to 400°F (200°C) or heat a skillet over medium-high heat.
In a small bowl, mix smoked paprika, cumin, garlic powder, salt, and black pepper.
Pat salmon dry, rub spice mixture evenly over the top, and drizzle with olive oil.
Cook salmon for 10 minutes or until flaked and tender (oven: 12-15 minutes). Let cool slightly.
Flake cooked salmon into coarse pieces. In another bowl, combine diced cucumber, red onion, and cilantro, mixing gently.
Fill each lettuce leaf with salmon and veggies, top with diced avocado, and serve with a drizzle of lime-honey Greek yogurt sauce (mix yogurt, lime juice, and honey until smooth).
Serve immediately or store in an airtight container in the fridge until ready to eat.